I. Do all people with Parkinson’s disease (PD) need surgery? Not all PD requires surgery. Stereotactic surgery is more effective for tremor and rigidity, and less effective for slow movement. It is generally considered that its surgical counterparts: 1) are under the age of 70, have ineffective long-term medication or significant side effects, and have greater restrictions on their ability to work and live; 2) are clinically graded II-IV and have no obvious contraindications to surgery-i.e., patients with severe hypertension, heart, liver, kidney, lung, or diabetes, cannot be operated on. 2. What are the preoperative tests required for Parkinson’s disease? 1, Parkinson’s disease preoperative need to carry out head CT examination, preferably MRI; to understand the presence of brain atrophy; 2, electrocardiogram; 3, blood biochemical examination – to understand the presence of diabetes, liver, kidney function and other conditions. How many surgical procedures are available to treat Parkinson’s disease? The current surgical treatment for Parkinson’s disease includes: 1) stereotactic targeted radiofrequency destruction (including the so-called cytoknife); 2) deep brain nucleus stimulation (DBS); 3) brain tissue transplantation. 4.How to choose the surgery for Parkinson’s disease? For Parkinson’s disease, choose stereotactic targeted disruption, for bilateral surgery, you can first perform disruption on one side and choose deep brain nucleus stimulation on the other side or choose deep brain stimulation on both sides. Is there any danger in Parkinson’s disease surgery? Parkinson’s disease surgery, like other brain surgeries, has certain surgical complications, but as long as the surgical indications are chosen appropriately, the incidence of surgical complications is low. The biggest complication is intracranial hemorrhage leading to hemiparesis. What complications can occur after Parkinson’s disease surgery? Intracranial hemorrhage, hemiparesis, speech disorders, swallowing difficulties, numbness of one limb, and balance disorders can occur after Parkinson’s disease surgery. Do I need to take medication again after Parkinson’s disease surgery? Parkinson’s disease surgery only relieves most of its symptoms, not curing it. In addition, surgery is performed on one side only, so medication is still needed after surgery, but the amount of medication can be reduced. Is there a “cell knife” for Parkinson’s disease? There is no such thing as a “cell knife”, but a micro-electrode recording system, which is an electrophysiological instrument to help the surgeon verify the correctness of the selected target. What is a micro-electrode recording system? A very thin electrode is sent into the target area in the brain by stereotactic technology, the end of this electrode is usually 1-2 microns in diameter, the exposed length of the tip is 15-140 microns, the outer layer is platinum or iridium coated; the electrode rod is insulated with epoxy resin and put into a 25 gauge stainless steel sleeve. The microelectrode is advanced with a helical micropropeller. This electrode enters the brain to draw out cellular bioelectricity from various locations, amplify, display and record the steps. It helps the surgeon to pinpoint the target area and understand its electrophysiological status. So it is not any cell knife. The relationship between microelectrode recording and “cytoknife” Microelectrode recording system is a so-called “cytoknife”, both are one examination instrument. This instrument is not a surgical “knife” used to remove lesions in the brain.