One of the most important concerns of rheumatology patients is the side effects of drugs, which is also one of the most difficult questions for doctors to answer in clinical practice. However, the issue of side effects is a headache for doctors and patients because it may cause adverse or even harmful results to patients, so it is important to strike a balance between beneficial and harmful effects so that they are not as adverse or as mild as possible to patients. The problem is one that requires a lot of attention. Generally, doctors should be well aware of the side effects of drugs when using them and regularly monitor the patient’s body, such as regular laboratory tests and so on, to adjust the drugs in a timely manner, in case of abnormal biochemical tests. Even stop using them. And timely use of gastric mucosa protection, as well as liver or kidney protection drugs to bring the patient’s health back to normal or better condition in a timely manner. Patients need to read the instructions carefully and consult with the treating physician in person if there is anything they do not understand. At the same time, according to medical advice timely follow-up. It is very important not to be careless. In order to avoid irreversible consequences. The results of medical treatment will be good according to the mutual wishes of the doctor and the patient.