GFR in medical terms indicates glomerular filtration rate, which is one of the indicators of renal function. the normal value of GFR is about 125 ml/min, so the total amount of plasma filtered by normal glomerulus in every 24 hours should be about 180 L, slightly higher in men than in women. Generally GFR is elevated, which may be related to physiological factors such as youth, good physical condition, high metabolic rate, and large amount of water intake. In contrast, pregnancy can cause an increase in renal blood flow due to the increase in blood volume in pregnant women, which can increase GFR. Higher intake of high protein diet, such as milk, lean meat, eggs, fish and soybean, can also cause an increase in GFR. In addition, increased GFR is often associated with disease factors such as diabetic nephropathy, hypertension, early kidney disease, and hyperthyroidism, and proteinuria may occur at the same time. A gradual decrease in GFR may occur with age. Ureteral obstruction caused by renal pelvis or ureteral stones, tumor compression, glomerulonephritis, systemic lupus erythematosus, uremic syndrome, etc. may also cause a decrease in GFR, which is often accompanied by increased serum creatinine and urea nitrogen test results. Generally, GFR needs to be detected by inulin clearance, blood retention method, plasma sample method, serum creatinine and creatinine clearance, blood urea nitrogen and clearance, etc. It is necessary to determine whether related diseases are present according to the patient’s age and weight.