Loose and painful teeth can be caused by periodontitis, dental trauma, acute apical periodontitis, etc. Specific treatments should be chosen according to the cause of the disease. 1. Periodontitis: If the loosening of teeth and pain is caused by periodontitis, you can use local minocycline gel, chlorhexidine acetate solution, oral amoxicillin capsules, roxithromycin capsules, metronidazole tablets and other medications, and at the same time need to carry out periodontal treatment such as scaling, scraping, but also flap surgery, bone grafting, guided tissue regeneration and other surgical procedures for treatment. 2. Dental trauma: If the symptoms are caused by dental trauma, the tooth can be loosened and fixed, oral amoxicillin capsules, cefuroxime capsules and other medications, and the pulp is exposed to the need for root canal treatment. 3. Acute apical periodontitis: root canal treatment is usually needed. When the tooth loosening and pain symptoms, should go to the hospital in a timely manner for relevant examinations, clear causes, under the guidance of professional physicians for targeted treatment and standardized use of drugs, to avoid the impact on the body.