Diabetic patients with thick and hard toe skin, if accompanied by sensory abnormalities, consider diabetic foot, need to seek medical treatment as soon as possible, if not accompanied by sensory abnormalities, consider and callus, keratosis pilaris, etc., can be used under the guidance of the doctor, salicylic acid ointment, compound benzoic acid ointment and so on. 1. Diabetic foot: it is a common complication of diabetes mellitus patients, which is mainly manifested by abnormal sensation, intermittent claudication, subtle deformation of joints, ecchymosis, thickening and cracking of the skin at the end of the toes, etc. If you have any of the above symptoms, you should consult a doctor as soon as possible for treatment. 2. Callus: people who walk for a long time, wear ill-fitting shoes or do heavy physical labor can have thick and hard toes, the symptoms are mild and can be relieved by replacing ill-fitting shoes, and the symptoms are serious and can be treated with salicylic acid ointment as prescribed by the doctor. 3. Keratosis pilaris: Consider fungal problems that lead to thick and hard toes, and use compound benzoic acid ointment, compound ketoconazole ointment and other medications under the guidance of a doctor. There are many other reasons for thick and hard toes, and diabetic patients with thick and hard toes are advised to go to the hospital, and should not blindly use medication on their own.