Clinical Study of Micropump Chemotherapy of Duration in 24 Hours [Abstract] Objective To explore the chemotherapy method with little side effects and best effect; Methods Micropump Chemotherapy of Duration in 24 Hours; Results Chemotherapy for a total of 30 cases of malignant tumors, with an efficacy of 73% and basically no side effects; Conclusion Micropump Chemotherapy of Duration in 24 Hours is an effective chemotherapy method. Fan Enxue, Department of Colorectal and Anal Surgery, The Second Hospital of Jilin University [Keywords]: Micropump Duration in 24 Hours Chemotherapy Malignant Tumors Clinical Study of Micropump Chemotherapy of Duration in 24 Hours [Abstract] Objective: We have been searching the best that in all methods that are available. searching the best that in all method in the patient with chemotherapy . Methods : Micropump chemotherapy of duration in 24 hours. Results :The 30 patients with malignancy tumor have been treated effectively by chemotherapy. There is the efficiency rate of 73% and nosecondary action . Conclusions : Micropump chemotherapy of duration in 24 hours is the best of all chemotherapy in world at present . [key words] Micropump chemotherapy of duration in 24 hours The patient with malignancy tumor Tetsuo Taguchi, President of the Asian Association for the Fight Against Cancer (AACC), said that chemotherapy for malignant tumors should be a surgeon’s business [1], and that at present the majority of patients who are treated with chemotherapy in Japan, Europe, and the United States receive treatment in a surgical setting. The majority of chemotherapy patients in Japan, Europe and the United States are now treated in the surgical department. Surgeons have a better understanding of whether a patient’s intraoperative tumor has metastasized and the degree of staging and differentiation, and it is easier to propose a specific plan for each patient. Individualized treatment plans for tumors should be the standard for each doctor to follow, and it is also the requirement of “evidence-based medicine”. We are exploring effective chemotherapy with low toxicity and side effects. Micropump continuous 24-hour chemotherapy is currently the most effective chemotherapy in the world, and is being recognized by doctors and patients. 1.1 General information 54 cases of malignant tumor patients were selected from October 1999 to March 2003, 23 male and 31 female, aged 57-79 years old, average age 67 years old, 30 cases of treatment group and 24 cases of control group were randomly set up, all of them were patients with recurrence of gastrointestinal cancer after operation. 1.2 Treatment Methods Micropump continuous 24-hour chemotherapy, with the following regimens: 1, fluoride + platinum drugs; 2, fluoride + hippocampus; 3, encycline + cyclophosphamide + fluoride, with individualized regimens based on the systemic status, tumor differentiation and staging, and implementation of international standard dosage. Two-week method. stable disease (SD), the sum of the products of the largest diameter of each lesion and its largest vertical shortcut increased by <25% or decreased by <50%, and confirmed by retesting at least 4 weeks later; progression disease (PD), the product of the largest diameter of at least one lesion and its largest vertical shortcut or a single diameter increased by more than 25%. 1.4 Determination of efficacy indexes Effective rate = complete remission + partial remission 2.2 Results 54 patients were all recurrent malignant tumors, after micropumping continuous 24-hour chemotherapy and non-micropumping continuous 24-hour chemotherapy, 73% of the patients in the treatment group had disease control, systemic status improvement, tumor survival, basically no serious chemotherapy complications (alopecia, leukopenia, serious changes in liver function), whereas the control group had an effective rate of only 29%, with serious chemotherapy complications, and the control group had an effective rate of only 29%, with serious chemotherapy complications. In contrast, the effective rate of the control group was only 29%, and there were serious chemotherapeutic episodes in the control group, the test P＜0.005, the clinical effect was remarkable. 3. Discussion In order to better improve the effect of chemotherapy, and constantly refine the optimal treatment program, the author after a large number of clinical trials, screening for the first, second and third line chemotherapy drugs suitable for the situation in northern China, the clinical effective rate of 73%, which is significantly higher than the effective rate of 20% of the 5-FU alone [2]. It was also higher than 30-40% [3] for any other combination chemotherapy regimen. The hematologic toxic side effects are between 1-3%, which are basically controllable, and there are basically no serious chemotherapy episodes (alopecia, leukocyte decline, severe changes in liver function), which are lower than those reported internationally, and the clinical effect is remarkable. Basic principle: 1. Maintain effective blood drug and concentration, and continue to kill tumor cells; 2. Extend the time of drug administration, and kill tumor cells entering the proliferative stage at different times; 3. Extend the contact time between drug and tumor cells, and enhance the efficacy of drug; 4. Reduce toxic side effects, and do not affect the normal work and life, and the patients all say, "I am not afraid of chemotherapy any more! Patients say "I am no longer afraid of chemotherapy". Chemotherapy can resist systemic micro-metastases, consolidate the efficacy of surgery, alleviate symptoms, and enhance the local cure rate. Chemotherapy has only been recognized by the medical community since the 1990s, and is currently in the stage of clinical trials. The following issues should be noted: 1) clear diagnosis; 2) biological characteristics of the tumor (stage, differentiation, etc.); 3) whether there is a standardized treatment plan for the tumor; 4) comprehensive evaluation of age, systemic status, complications, etc.; and 5) obtaining the informed consent of the family. Chemotherapy is not suitable for all tumor patients. Individualized treatment plan with high sensitivity that can improve survival and reduce complications should be selected. At the same time, danshen and Vit B6 can be added to reduce the toxic reaction and increase the efficacy; oral selenium preparation and retinoic acid can be used to improve the anti-tumor immunity. For chemotherapy-resistant can be added transgenic therapy (such as Faloton), etc., to increase the efficacy, during the chemotherapy should be dynamic monitoring of blood, liver, lungs, there are changes at any time to adjust the chemotherapy program, for the recurrence of the patient can be combined with chemotherapy or a small dose of continuous chemotherapy, to reduce toxicity reactions, prolong the survival period. For local recurrence, advanced patients who cannot be resected at one time, and patients with liver and lung metastasis, radiotherapy can be given first, and then surgery can be performed after the tumor is downstaged, and the five-year survival rate will be the same as that of one surgery. In conclusion, micropump continuous 24-hour chemotherapy is effective and has low toxic reaction. Especially for advanced patients, small-dose continuous chemotherapy can reduce the toxic symptoms of advanced tumor patients and prolong the survival period of patients with tumors, which is worthy of clinical promotion and application. 4.References 1 Tetsuo Taguchi, The status of adjuvant chemotherapy in surgical oncology treatment and the application of fluorotelomer. The First Roche Sino-Japanese Academic Conference on Surgical Treatment and Research of Tumors. Shenyang: 2001;5. 2 Buyse M,Zeleniuch-jacquotto A,Chalmers TC.Adjuvant therapy of colorectal cancer .Why we don't know .JAMA,1998;259:3571-3578. 3 Connel MJ,Maill-ard JA,Kahn MJ,et al .controlled trail of fluorouracil and low dose lenco vorin given for 6 months as postoperative adjuvant therapy for colon cancer .J Cli Dncol,1997;15:246.