Diabetic nephropathy stage III is generally possible to maintain 30 years if the condition is well controlled to prevent further deterioration of the disease. It is recommended that patients with diabetic nephropathy stage III should go to regular hospitals in time and follow the doctor’s instructions to actively standardize the diagnosis and treatment. Patients with diabetic nephropathy stage III usually have a significant increase in proteinuria, may have mild hypertension, glomerular filtration rate decreased, but blood creatinine is normal. Renal pathology shows focal/diffuse sclerosis, hyalinosis of inlet/outlet glomerular arterioles and so on. Usually, after symptomatic treatment through active and standardized control of blood glucose, blood pressure, reduce proteinuria, reduce edema and so on. If the patient’s condition is well controlled, not let it continue to deteriorate and slow down the process of renal function damage, the patient is likely to maintain 30 years. It is recommended that patients with diabetic nephropathy stage III should seek medical treatment in time and actively cooperate with professional doctors and follow the doctor’s instructions in order to slow down the progress of diabetic nephropathy and improve the survival time of patients.