What are the confirmatory results of laboratory tests for primary aldosterone syndrome?

Primary aldosterone syndrome is correctly diagnosed as primary aldosteronism, which is confirmed by laboratory tests: if blood aldosterone levels are not suppressed after using the captopril suppression test, this suggests a confirmed diagnosis of primary aldosteronism. Diagnosis and treatment under a physician’s supervision is recommended. According to the 2016 Expert Consensus on the Diagnosis and Treatment of Primary Aldosteronism, the diagnosis of primary aldosteronism must be clarified by one or more tests to avoid overdiagnosis. Currently, the following tests are commonly used in clinical practice: 1. Captopril inhibition test: normal people taking captopril can inhibit angiotensin Ⅰ into angiotensin Ⅱ, make angiotensin Ⅱ reduce, so as to inhibit the secretion of aldosterone, if the blood aldosterone level is not inhibited after taking it, it can suggest the confirmation of the diagnosis. 2. Saline infusion test: normal people infused with saline, the increase of blood sodium and blood volume, will inhibit the secretion of angiotensin – aldosterone, but autonomous secretion of aldosterone in patients with primary aldosteronism, there is no obvious inhibitory effect, the measurement of blood aldosterone > 10ng / dl can be diagnosed. In addition, there are fludrocortisone test and oral high sodium test, primary aldosteronism must be diagnosed by specialized doctors based on a combination of examination and test results.