Patient: I was tested in 2005 for chronic hepatitis B, major triple positive, and started taking lamivudine in July 2006. I was tested for drug resistance in July 2007 and switched to Adefovir and have been taking Adefovir since then. What should I do if it is Adefovir resistance? Please help the doctor to diagnose. I’m looking forward to hearing back! Li Jun, Department of Infection Medicine, Jiangsu Provincial People’s Hospital: It is best to combine treatment with adefovir after lamivudine resistance. Treatment with adefovir alone will tend to increase the generation of resistance to adefovir. It is best for you to undergo multi-locus resistance gene testing to facilitate the rational selection of drugs for your subsequent treatment. Our department can perform such a test. Patient: Please ask Dr. Li (multi-locus resistance gene testing) I am from out of town when is the best time for me to go and get the test results quickly. And your address and contact information! The Department of Infectious Diseases, Jiangsu Provincial People’s Hospital, Li Jun: Our hospital is open 6 days, and the outpatient clinic is closed only on Sundays. Our department is in the 9th building of our hospital (Infectious Diseases Building), and the clinic contact number is (025) 8371186-6375, and the address is No. 300, Guangzhou Road, Nanjing. The test results can be mailed. Patient: Hello Dr. Li, I just got my test results and uploaded them to my medical record (liver function), please take time to read them. Give me some guidance. Li Jun, Department of Infection Medicine, Jiangsu Provincial People’s Hospital: Your test results show mainly lamivudine resistance, with 204-bit resistant variants, but because there are also 180-bit resistant variants, some people may be slightly less effective against adefovir, and it is recommended that you still lamivudine combined with adefovir treatment, or entecavir combined with adefovir treatment.