Auntie Ma is 56 years old this year, a few years ago got diabetes, although after treatment, the blood sugar does not fall but rises, even the blood pressure and blood lipids are not normal. Also feel headache, speech slurred, suspected of diabetes complications. She went to the endocrinology department of Ruijin Hospital. The physician first carefully measured her, and then asked Auntie Ma whether her shoe size had become larger in recent years; whether her fingers had become thicker; whether her voice had become lower; and whether her appearance had become harder to see. Auntie Ma froze, she had all of the above, but hadn’t really noticed if the doctor hadn’t mentioned it. When she took out her photos from years ago, she was really ugly, no wonder people on the street were always looking at her with astonishment. After examination, it was found that the level of growth hormone in the blood was very high, and a 3-centimeter tumor had grown in the pituitary gland of the brain. Zhang, a 24-year-old college student, had been suffering from menstrual disorders for a long time, as well as a voice like a boy’s, and went to the endocrinology department for treatment. Fortunately, the doctor’s eyes like a torch, immediately noticed Zhang 1.86 meters tall and special face, further investigation found that she was 12 years old has been 1.8 meters of the small giant, and Zhang has long been accustomed to the crowd’s “look up”, do not think that the disease. This is destined to make her difficult to “low profile”, many basketball coaches want to recruit her. But they were all rejected by her on the grounds that she didn’t love sports. Don’t look at her tall and big, in fact, she is “empty mold”, a little activity on the chest tightness, shortness of breath, not to mention sports. After examination, it was found that her blood growth hormone level was very high and there was a 0.7 cm tumor in the pituitary gland. They are suffering from endocrine diseases known as “acromegaly” or “gigantism”, almost all of which are caused by pituitary tumors, with an incidence rate of only 6 to 18 per million, of which tumors with a diameter of less than 1 cm are known as “microadenomas”, which are very dangerous to health. Among them, tumors less than 1 cm in diameter are called “microadenomas”, which are very harmful to health. Most patients’ condition progresses slowly, and changes in appearance and body shape are difficult to be detected at an early stage. Often due to hormonal changes, symptoms or complications arising from tumor compression, they go to the doctor, but fail to get timely and correct diagnosis and treatment, which seriously affects their health and quality of life and leads to a shortened life expectancy. Due to the lack of sufficient awareness of this rare disease, the current situation of the “giant family” is not optimistic, because of its special physical appearance, wrongly regarded as a “powerful group”, and often play the role of “giant Because of their special physical appearance, they are wrongly regarded as a “powerful group” and often play the roles of “Big Mac”, “Hercules” and “super fighter” in the society and movie productions, and very few people pay attention to the pain behind them. The first choice of treatment for acromegaly is surgery, followed by medication or radiation therapy. If the surgical conditions are poor or inoperable, drug therapy can be chosen to create better surgical conditions, or it can be applied for a long period of time to relieve symptoms and control the condition. Among the various drugs, growth inhibitor analogs such as Lanreotide acetate are the most effective. Radiation therapy is ineffective, slow-acting and has many side effects. Auntie Ma’s tumor had already pressed on the optic nerve and was adjacent to a blood vessel, so it was impossible to remove the tumor completely, and she had to choose medication first. After 6 months of treatment with growth inhibitor analogs, the tumor shrunk significantly. The doctor performed surgery to remove the tumor, but the growth hormone was not completely normalized, and it was only after growth inhibitor analogs that the tumor could be controlled. The doctor told her to review the tumor at least once a year, and it is best to control it with long-term medication, which can be insufficient because the medication is expensive. Xiao Zhang’s growth hormone tumor was found in time and was well suited for minimally invasive surgery. After the surgery, the growth hormone decreased rapidly, the signs and symptoms caused by too much growth hormone could be improved or relieved, and menstruation resumed, but like Auntie Ma, regular checkups were still needed.