When “open”, the whole body is clear, as if entering the light from darkness, all the physical symptoms disappear, and you can move freely. When “off”, it is the opposite, as if walking with shackles and a hammer on one’s feet, making it difficult to walk. This is probably what many people with Parkinson’s disease experience when they experience the on/off phenomenon. Perhaps only Parkinson’s patients can understand this feeling. Drugs are often a double-edged sword, and the switch phenomenon is a fluctuation in the efficacy of levodopa drugs in Parkinson’s disease patients after long-term application. As the basic drug in the treatment of Parkinson’s disease, levodopa drugs were used with good results in early clinical use. Since its use in 1968, it has had a significant effect on eliminating motor symptoms, tremor, rigidity, reduced and slow movements in Parkinson’s disease. However, after 3 to 5 years of taking levodopa-based drugs, the limitations of the drug will appear, and long-term use will cause pathological changes in brain tissue, which in turn will cause various motor complications, and the switching phenomenon is only one of the side effects. The “switch” changes the patient’s lifestyle, and the unique side effects of taking the medication can have a profound impact on the lifestyle of Parkinson’s disease patients and seriously affect their quality of life. Of course, in addition to the switch phenomenon, there are many other side effects associated with taking medication, such as the common end-of-dose phenomenon. This refers to the increasingly short duration of drug maintenance and the worsening of symptoms of Parkinson’s disease that occurs late in each dose. In addition, after taking the drug, although it improves symptoms such as tremor, most patients will also experience anomalous movements. Dance-like or simple repetitive involuntary movements can occur in the facial muscles, neck, back and limbs. These involuntary movements can be large in magnitude and can last for the entire onset of levodopa-like drugs. Currently, deep brain electrical stimulation can be an effective treatment for Parkinson’s disease. Deep brain electrical stimulation is a stereotactic procedure in which stimulation electrodes are implanted into the lesioned areas of the brain in Parkinson’s disease. A stimulation generator is implanted under the skin in the patient’s anterior chest, and electrical pulses are used to stimulate specific areas of the brain to improve symptoms of the disease such as primary tremor, tonicity, and motor retardation. Deep brain electrical stimulation for Parkinson’s disease has strict indications and can be used for patients whose effects have waned after several years of medication and who have developed serious complications, and the patient must not have severe systemic disease.