(Disclaimer: This article is only for scientific purposes, in order to protect the privacy of patients, the following content of the relevant information has been processed) Abstract: Hypoventilation syndrome is often associated with obesity, there is no specific drug treatment for this disease, but through weight loss and noninvasive positive airway pressure ventilation, can improve the patient’s symptoms very well. In this case, the patient was obese and came to the clinic because of daytime sleepiness, fatigue, dry mouth, inability to concentrate and memory loss. After diagnosis of hypoventilation syndrome, the patient was actively treated with weight loss and noninvasive positive pressure ventilation, and his symptoms eventually improved and he recovered his health. Basic information] Male, 55 years old [Disease type] Hypoventilation syndrome [Hospital] Wuhan University People’s Hospital [Time of consultation] June 2019 [Treatment plan] Weight loss + non-invasive positive airway pressure ventilation [Treatment cycle] Continuous treatment for 2 months [Treatment effect] Daytime fatigue, drowsiness and other symptoms improved, weight loss A. Initial consultation The patient, Lao Zhang, is a 55 year old male with a relatively obese body type, who had a tired face and a memory loss when he came to the clinic. When he came to the clinic, his face was tired, and he said that he often woke up at night, always wanted to sleep during the day, and had trouble concentrating at work, accompanied by memory loss. The patient’s family said that the patient snores at night, and the sound of snoring is quite loud. Combined with the above symptoms, it can be initially judged that the patient has hypoventilation syndrome, which is a disease in which the upper airway collapses and becomes obstructed repeatedly during sleep. Due to the lack of oxygen at night and repeated waking up, the patient would experience daytime weakness, sleepiness, memory loss, open-mouth breathing and other symptoms. As the patient was suspected to have hypoventilation syndrome, sleep apnea monitoring was performed on the patient, and the results showed that the number of hypoventilation and waking up after falling asleep was high, and the level of oxygen saturation was low at night, etc., according to which it could be judged that the patient had hypoventilation syndrome. In addition, combined with the patient’s physical condition, obese body type, BMI suggesting obesity, etc., the condition is considered to be due to obesity, and therefore the patient is recommended to undergo weight reduction treatment, including dietary control for the patient, such as controlling the amount of diet, eating less high-sugar and high-oil food, as well as moderate exercise to consume excess body fat through exercise. In addition, as the patient also had hypoxia and suffocated waking at night, so the patient was given non-invasive positive airway pressure ventilation treatment to improve hypoxia. Treatment effect Through diet control and moderate exercise, the patient’s weight decreased continuously, and she lost 10 kg in one month, and after noninvasive positive airway pressure ventilation, the patient’s waking up at night disappeared, her sleep quality improved, and her daytime drowsiness, fatigue, lack of concentration, and memory loss due to the short sleep time at night were relieved. During the treatment period, the patient reported dry mouth due to noninvasive positive airway pressure ventilation, but this is a normal reaction to this treatment. We introduced and reassured the patient in detail and told the patient that there was no need for special treatment, and that he could just strengthen his daily water intake. After 2 months of treatment, the patient went to the hospital for review and sleep apnea monitoring was performed again, and the results suggested that all indicators had improved. IV. Precautions We are glad that after a series of treatments, the patient was able to lose weight, the situation of waking up at night disappeared, the quality of sleep was greatly improved, and the situation of inattention and memory loss were significantly relieved, and all the indexes have been improved, but the patient still needs to pay attention to the following points in his daily life: 1. Diet: Diet should be continued to be controlled, and should not be binge eating because of improvement of the disease, but still should be Pay attention to eat less fried chicken, barbecue and other fried, greasy, high-calorie food, but also eat less pastries and other high-sugar food; 2, exercise: it is recommended that the patient appropriate aerobic exercise, such as running, swimming, jumping rope, riding a bicycle, etc., but it should be noted that the intensity can not be too strong at the beginning of the exercise, should be gradually increase the amount of exercise, should pay attention to the stretch before and after the exercise, to avoid injuries; 3, other: the patient should pay attention to quit smoking and limit alcohol, should try to sleep, and should be able to sleep, should pay attention to the following points Limit alcohol, sleep should try to sleep on the side, can reduce the chances of upper airway obstruction, but also conducive to the alleviation of the disease. If symptoms such as daytime sleepiness recur, they should go to the hospital in time. V. Personal perception Many obese patients may have symptoms of hypoventilation syndrome such as snoring at night, waking up with suffocation, daytime sleepiness, and fatigue, etc. However, due to the fact that the general public has little knowledge of the disease, they may think that it is just snoring, which is not so much of a disease, and does not lead to much serious consequences, and therefore neglect the treatment of hypoventilation syndrome. However, in fact, severe hypoventilation syndrome may cause a series of target organ damage, such as may cause hypertension, cardiac arrhythmia, diabetes mellitus and so on. The patient in this article suffered from hypoventilation syndrome, which led to a series of complications, including drowsiness, fatigue, inability to concentrate, and gradual decline in memory, etc. This is a typical manifestation of hypoventilation syndrome, but fortunately, because of the patient’s early detection, the patient’s symptoms have been significantly improved after active treatment, and all the indicators have improved. Therefore, if symptoms such as snoring and daytime sleepiness occur, we need to seek timely medical treatment to correct them.