Chronic cerebral hypoperfusion is a series of pathophysiological changes in the brain caused by long-term cerebral hypoperfusion from various causes, which mainly manifests clinically as progressive learning p memory and other cognitive dysfunctions, and is a common pathological process in the development of various diseases such as vascular dementia, Alzheimer’s disease and Bingswanger. Chronic cerebral hypoperfusion injury is a long-term slowly progressive process, with damage early in the onset mainly at the subcellular and molecular levels, with mild clinical manifestations. In the later stages of the disease, extensive brain damage leads to irreversible dementia symptoms, and patients’ quality of life is severely impaired, and at this stage, clinical treatment methods and means are extremely limited and ineffective. Therefore, the study of its pathogenesis and its prevention is particularly important.