Metastasis of malignant isolated fibrous tumors can cause systemic symptoms that can affect the patient’s life expectancy if the condition is severe. When malignant isolated fibrous tumor spreads to lymph nodes, it will lead to enlargement of lymph nodes, pain in lymph nodes and formation of lumps. Metastasis to the brain will cause nausea, vomiting, headache and impaired consciousness and other symptoms, and in severe cases, may cause coma. When malignant isolated fibrous tumor metastasizes to the lungs, it will cause patients to have blood in sputum, chest pain, dyspnea and so on. Metastasis to the bones will lead to bone pain and fracture easily. When malignant isolated fibrous tumor metastasizes to organs, it will cause the function of each organ to be impaired, resulting in systemic dysfunction, which will endanger the patient’s life in serious cases. Malignant isolated fibrous tumor should be treated in time to avoid aggravation of the condition and metastasis.