Severe heat stroke if high fever does not subside: first, lower the body temperature, such as intravenous antipyretic drugs, commonly used lysine, but also combined with physical cooling, such as warm water baths, alcohol baths, etc.. You can also use physical cooling methods, such as ice blankets, ice caps, and continuous hemofiltration. Second, the electrolytes in the body must be replenished to correct the imbalance of electrolytes in the body, and also try to replenish water as much as possible. Third, if coma occurs, naloxone can be used to promote awakening. In addition, Chinese medicine’s Waking Brain Jing also has the effect of enlightening and promoting awakening, which is very effective for high fever, convulsions and coma. Fourth, if convulsions occur, sedation must be given immediately, commonly used drugs are diazepam or phenobarbital. If heatstroke appears respiratory and cardiac arrest, cardiopulmonary resuscitation, epinephrine and other drugs should be given immediately to rescue treatment.