Frequent pinching of the toes may have some benefits for diabetic neuropathy, for example, can promote blood circulation, but the benefits are limited, should be taken under the guidance of the doctor to lower blood sugar, nutrient nerve and other drugs treatment. Pinching the toes can play a role in promoting blood circulation in the lower limbs, tendon relief and other effects, but the role is limited. Diabetic patients with long-term poor blood sugar, high sugar toxicity may damage the nerve, and microangiopathy, oxidative stress damage and other factors can induce diabetic neuropathy. Therefore, diabetes mellitus should be standardized treatment under the guidance of a doctor, control of blood glucose, blood lipids, blood pressure, to a large extent, can avoid the production of diabetic neuropathy; for patients who already suffer from diabetic neuropathy, should be on the basis of the above for the treatment of neuropathy. Patients diagnosed with diabetes mellitus or diabetes mellitus combined with neuropathy should actively cooperate with doctors for treatment.