Overall, anti-hypertensive drugs are clinically safe at present, but this does not mean that any one anti-hypertensive drug is appropriate for every hypertensive patient. Patients must choose the right drug according to their own situation, and if abnormalities occur, promptly inform the doctor and ask him/her to determine whether it is a side effect of anti-hypertensive, and if so, promptly adjust the drug. It is important for every hypertensive patient to correctly understand the side effects of anti-hypertensive drugs. In addition to common side effects such as hypotension, rash and gastrointestinal reactions, the side effects of different types of drugs vary, including: 1. cough: mainly occurs with vasoprenalin converting enzyme inhibitors, such as captopril, benazepril and enalapril, characterized by dry cough without sputum, itchy throat and metallic taste, more in the morning. 2. Facial flushing: mainly occurs with calcium antagonists, such as amlodipine, nifedipine and felodipine, and is characterized by flushing of the cheeks and a feeling of facial burning, which is more pronounced in sunlight exposure. Ankle edema: also seen with calcium antagonists, confined to bilateral ankles, mild to moderate edema, usually not accompanied by shortness of breath and decreased urination. 4. Dry stools: seen with calcium antagonists. 5.Conduction block and bradycardia: seen with beta-blockers, such as bisoprolol, metoprolol, and aurolol, etc. Sometimes the heart rate is below 60 beats per minute or even lower, and the ECG may also be accompanied by varying degrees of conduction block. 6, male hypogonadism: seen in beta-blockers. 7, electrolyte disorders: seen in angiotensin for enzyme inhibitors and diuretics, the former has a potassium-protective effect, such as when used in combination with potassium-protective diuretics prone to hyperkalemia, so should be used with caution, the latter, such as furosemide, hydrochlorothiazide, etc., prone to hypokalemia. 8, the effect on metabolism: mainly cause elevation of blood sugar and uric acid, seen in diuretics. Effective ways to avoid these side effects include: individualization of drugs, that is, according to the patient’s condition, age, gender, and different concomitant diseases and the use of different drugs, such as age over 70 years old, the base heart rate is slower should not use beta-blockers, with diabetics caution diuretics, etc.. Most drugs have side effects within a certain range related to the dose, the higher the dose, the greater the possibility of side effects, so choose to start with a small dose. The combination of different types of drugs can sometimes offset the side effects, such as the combination of potassium-depleting diuretics and potassium-preserving diuretics, and the combination of drugs that increase the heart rate and drugs that slow it down.