Otitis media is too painful to sleep at night, considering acute purulent otitis media, the tympanic membrane is not perforated due to the local medication, systemic medication, surgical treatment and other measures can be taken. 1. Local medication: 2% glycerin carbolic acid can be used, with anti-inflammatory and pain-relieving effects, note that the tympanic membrane should not be used after perforation. 2. Systemic medication: Acetaminophen, ibuprofen, aspirin and other anti-inflammatory and analgesic drugs can be taken to relieve the symptoms of pain, and penicillin is the preferred antibiotic treatment. 3. Surgical treatment: If the accumulation of pus in the tympanic chamber does not occur without tympanic membrane perforation, the pus can be discharged through incision of the tympanic membrane to relieve the pain. Otitis media is too painful, the night pain can not sleep, it is recommended to go to the regular hospital in a timely manner to check, clear cause and condition, follow the doctor’s instructions standardized medication and treatment.