Parkinson’s disease is second only to tumors, cardiovascular and cerebrovascular diseases after the third major health hazards of middle-aged and elderly diseases, with the increase in the number of people with the disease, more and more attention. However, patients and their families only know the diagnosis written on, “Parkinson’s disease”, “Parkinson’s syndrome”, thinking that all are Parkinson’s disease, are the same treatment. However, in the outpatient clinic, we often see such a situation, patients who do not know each other will be Parkinson’s disease and chat a few words or acquaintance, the opening sentence is mostly “How many years have you been sick?”. Some patients with seven or eight years, or even more than 10 years, visible hand tremors, walking slowly, taking medication is effective, the spirit can be, but some patients with two or three years of severe disease to the inability to walk, sitting in a wheelchair, can not take care of their own lives, many family members do not understand what is going on? This year’s 75-year-old Ms. Jiang, accompanied by family members to the clinic, complaining of walking slow, clumsy movements, unsteady, fall backward need to be assisted, walking difficulties, standing, sitting, turning over, dressing are difficult to complete alone, the left arm pain, choking on drinking water, slurred speech, nocturia, constipation, the patient is conscious. He was hospitalized for further treatment. Admission to the hospital for psychiatric scale testing showed that the patient was cognitively impaired with very poor spatial and executive abilities. Cranial magnetic resonance imaging showed soft foci in the right thalamus, demyelination in the bilateral lateral paraventricular and hemi-oval centers, and cerebral atrophy, and symptoms did not improve significantly with the administration of methyldopa, semiflora, and butylphosphatidylcholine capsules. Why Ms. Jiang’s Parkinson’s disease developed so fast and so severe, the family did not understand, in fact, Ms. Jiang’s diagnosis is Parkinson’s disease superimposed syndrome, which is not the same as primary Parkinson’s disease. Parkinson’s disease superimposed syndrome is a group of neurodegenerative disorders with clinical manifestations similar to those of Parkinson’s disease and characterized by other neurological lesions. The etiology of Parkinsonian superimposed syndrome is unclear, and the clinical symptoms are similar to those of Parkinson’s disease, but the range of symptoms and lesions is broader than that of Parkinson’s disease, also known as multi-system degeneration, which includes progressive supranuclear palsy, corticobasal ganglion degeneration, diffuse Lewy body disease, postural hypotension syndrome, striatonigral nigrostriatal degenerative disease, and olivary-bridgety-cerebellar atrophy, etc., among which postural hypotension syndrome, olivary-bridgety-cerebellar atrophy, striatonigral atrophy and olivary-bridgety-cerebellar atrophy are the most common. cerebral atrophy, and striatonigral nigrostriatal degeneration disease, also known as multiple system atrophy. Primary Parkinson’s disease also belongs to the central nervous system degenerative diseases, the main pathology is the degeneration and death of dopaminergic neurons in the nigrostriatum of the midbrain, causing a reduction in the production of dopamine neurotransmitters and triggering a series of limb movement disorders. The reason for what causes this change in pathology remains unclear. In diagnosis, Parkinson’s disease treatment experts based on the patient’s medical history, course of the disease, clinical symptoms and signs, combined with pharmacological diagnosis, primary Parkinson’s disease taking Medopa, Antan and other drugs are effective. General auxiliary examination is mostly without abnormal changes.