In terms of anesthesia alone, a single general anesthetic is usually not harmful to the brain, but a certain amount of physical discomfort may occur after the procedure, such as dizziness and nausea, and the corresponding reactions may disappear after the effects of the anesthetic drugs wear off. In the case of brain diseases or surgery performed in the brain, the influencing factors are usually both of these, rather than the factor of performing a single general anesthesia. General anesthesia methods include inhalation anesthesia, intravenous anesthesia, and combined static and inhalation anesthesia, and the blood concentration of anesthetic drugs in the center can be regulated regardless of the method used. After a general anesthesia, the patient’s consciousness and various reflexes can be restored after the effects of anesthetic drugs dissipate, so generally do not affect the brain. After general anesthesia, the patient’s systems and organs are usually in a state of tolerance to surgical injury and can help complete the surgery, so there is usually no need to worry. A thorough evaluation is performed prior to general anesthesia, and the patient should be detailed and honest with the anesthesiologist about his or her condition. If a patient deliberately hides his or her condition, the possibility of brain damage from a single general anesthetic cannot be absolutely ruled out, and the extent of the damage is usually incalculable. Some patients may have mild brain damage after a single general anesthetic, and some may have life-threatening damage.