Definition and Consensus of Tumor

Definition of tumor: Normal cells in biological organism are formed by the long-term effect of many internal factors (including genetic, endocrine disorders and malnutrition, stress, etc.) and external factors (including physical, chemical, biological, etc.) with qualitative changes and thus have the ability to overproliferate. This kind of abnormal proliferation is neither in accordance with the normal cell growth law nor the physiological needs. Tumor consensus: 1. Tumors come from cells of the body, not from outside. 2. Tumors are a group of cells that have undergone qualitative changes under the long-term effects of various external factors including physical, chemical and biological, and thus have the characteristic of abnormal overactive proliferation. This proliferation is neither physiological nor controlled by normal regulatory mechanisms. 3. In the formation of tumor, endogenous factors are also important. The proven ones are genetic, nutritional and endocrine disorders, cellular immune deficiency and long-term excessive stress response such as mental tension and other adverse stimuli. 4. At the cellular level we can see the dysfunction of various immune cells such as macrophages, T lymphocytes and natural killer cells (NK); at the molecular level we can also see the loss of control genes or oncogenes (e.g. p53, p16). All these can be understood as the category of “positive deficiency” in Chinese medicine. 5.For prevention and treatment, we can divide the development of tumor into the following five stages: precancerous stage – cells have undergone certain changes, but still not cancerous, and can develop in both directions; carcinoma in situ (generally called stage 0) – cells have just undergone malignant changes (e.g. epithelial layer); invasive carcinoma (generally represented by T) – cells have moved from the site of occurrence Local or regional lymph node metastasis (generally represented by N) – cells have been transferred to lymph nodes along the lymphatic vessels from the tissues where they occurred; Distant dissemination (generally represented by M) – tumor cells have been transferred to distant organs with blood flow. 6. Since tumor is a very heterogeneous disease, not only the clinical manifestations are different, but also the treatment is very complicated. So far there is no simple treatment or drug that can cure all tumors. Most tumors can be prevented. Although there are various treatments, comprehensive treatment is the principle.