Recently, foreign scholars Schmidt SAJ et al. found through a study that taking some antihypertensive drugs may increase the risk of skin cancer. In that study, they focused on the relationship between taking antihypertensive drugs and squamous skin cancer, basal cell carcinoma, and melanoma. In this case-control study, the researchers studied and analyzed a population-based database that included squamous carcinoma (2,282 cases), basal cell carcinoma (17,242 cases), and melanoma (3,660 cases) from 1991-2010 in northern Denmark. Using risk factor setting sampling for age, sex, and geographic region matched to 10 controls, by adjusting for coexisting disease and combined medications and further analyzing medication duration (less than 5 years and more than 5 years) and medication intensity, the investigators found that: 1. Patients who had used diuretics had an increased risk of squamous cancer, and long-term use of potassium-preserving diuretics alone or thiazide diuretics could increase the risk. 2. The use of sulfonamide and non-aldosterone antagonist potassium-preserving diuretics increased the risk of melanoma and basal cell carcinoma, as did the combination of thiazides and potassium-preserving diuretics. 3, Long-term low and high dose use of angiotensin receptor blocking agents is associated with melanoma. 4. The investigators found that angiotensin-converting enzyme inhibitors, Β blockers, and calcium antagonists were not associated with these tumors. This study is a retrospective study suggesting a correlation between the development of skin cancer and certain antihypertensive drugs in certain white populations in Northern Europe. We know that the incidence of skin cancer is much higher in Caucasians than in other people of color, and different sensitivity to drugs has been found in clinical studies in different ethnic groups. Therefore, our hypertensive patients should not be alarmed by this study; in fact, the benefits of aggressive hypertension control far outweigh the adverse effects of the drugs, as shown by the large number of studies so far.
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