As gene sequencing technology has improved, prices have dropped significantly, but are not covered by health insurance reimbursement and require patients to bear the cost. Checking a gene package, usually hundreds of genes, costs up to $5,000. Many doctors, without any general knowledge of genetic diseases, prescribe genetic screening to patients at will, especially when some of the results given are not well interpreted, with positive results causing psychological burden on the patient and negative results leading to a drop in the bucket. First of all, not all patients need to go for genetic screening. Second, not all doctors have the ability to interpret. Third, the state should legislate who can interpret. However, for patients with genetic possibilities, checking is necessary, and it should be done in detail. Second-generation sequencing does not work, and must be supplemented by first-generation sequencing. Many that do have genetic diseases are instead missed, especially surgeons, who do not pay careful attention to genetic issues and operate on many patients with genetic mutations.