The drug treatment of epilepsy in children is divided into traditional antiepileptic drugs and new antiepileptic drugs. Traditional antiepileptic drugs mainly include phenobarbital, valproic acid, carbamazepine, phenytoin sodium, clonazepam, etc. New antiepileptic drugs mainly refer to the drugs that have been marketed after the 1990s, and the new antiepileptic drugs that are commonly used in China at present include lamotrigine, levetiracetam, oxcarbazepine, topiramate, and zonisamide. The drug treatment of epilepsy in children should follow the general treatment principle and also consider individualized differences. When choosing therapeutic drugs, full consideration should be given to the characteristics of each child with epilepsy, such as etiology, epilepsy type, co-morbidities, and family factors, etc., and certain principles of medication need to be followed during the medication period in order to achieve a better effect, as follows: 1. First, drugs should be selected according to the type of epilepsy, and if the diagnosis can not be confirmed, the drugs can be selected according to the type of seizure; 2. First, monotherapy can be used, and if it is necessary to discontinue the medication, the medication should be discontinued slowly. The process of drug reduction and discontinuation generally requires more than 3-6 months, if you need to replace the drug, it should also be a gradual transition; 3, the course of treatment should be long, generally need to be treated for at least 2 consecutive years without seizures, and the EEG epileptiform discharges completely or basically disappeared, in order to begin to gradually reduce the drug; 4, in the whole treatment process should be followed up regularly, in order to prevent the emergence of adverse reactions, such as allergies, liver function injury, etc..