The retention time of wrinkle removal needles is related to the type of wrinkle removal needles, which should be analyzed on a case-by-case basis and not be generalized. It is a common cosmetic tool nowadays, easy to operate, little damage and fast results. One is the injection of botulinum toxin, so that facial expression muscle contraction is somewhat inhibited, so as to achieve the effect of reducing wrinkles. With time, the nerve function gradually recovers, so that the muscle returns to normal and the effect of wrinkle reduction disappears, which usually takes 4-6 months. Another kind of injection is hyaluronic acid, which can enhance the skin moisturizing and nutritional ability, making the skin elastic, thus removing wrinkles, but the human body will absorb these substances, and the ability to remove wrinkles will be weakened after absorption, which can generally be maintained for 5-7 months. After wrinkle injection, patients need to pay attention not to wash the face, makeup, etc. within 6 hours to avoid the spread of injections. Usually, they should avoid strenuous exercise, pay attention to diet and avoid spicy food.