Normal sperm resemble tadpoles and are ovoid in shape, and need to be viewed under a microscope magnified several hundred times. Sperm can be distinguished into head, body and tail, and there is also the body called the neck. Just as people in our society can have disabilities, human sperm can also have developmental abnormalities that manifest under the microscope as oddly shaped forms, some of which are normal physiological variants, while others fall into the category of malformations, such as head malformations, body malformations, tail malformations and mixed malformations. In general, abnormally shaped malformed sperm are more than 85% and can affect the ability of sperm to “capture” the egg, leaving a man’s fertility in jeopardy. In fact, there are so many medical uncertainties that even if the offspring are conceived and delivered naturally without IVF, they may not all be healthy! Fetal malformations occur mainly in the early stages of a woman’s pregnancy (within the first trimester). If during this period the pregnant woman is infected with pathogens, has a fever, takes harmful drugs (antibiotics, hormones, neurotoxic drugs, etc.), is exposed to environmental risk factors (alcoholism, pesticides, radiation), etc., this will directly endanger the process of fetal organ differentiation and lead to fetal malformations or developmental arrests. Thus, it seems that fetal malformations are not necessarily associated with sperm malformations. During the clinical treatment of IVF in humans, it has been found that teratozoospermia does not affect the treatment success rate of intra-ovarian single sperm injection (ICSI) technique and is usually not associated with fetal malformation. IVF babies born in recent years have answered this question with the same conclusion by living “human evidence”. Of course, it is entirely possible that some malformations may occur in children born from IVF as in normal pregnancies, and there is no significant difference in the incidence of fetal anomalies between IVF and natural births. Studies carried out on animal bodies have demonstrated that the risk of birth of such malformed offspring is minimal.