1. What is the safe range of platelet value for general surgery in patients with thrombocytopenic purpura? Oral examination: ≥10 × 109/L; tooth extraction/fillings: ≥50 × 109/L; minor surgery: ≥50 × 109/L; major surgery: ≥80 × 109/L; normal transvaginal delivery: ≥50 × 109/L; cesarean section: ≥80 × 109/L. For patients who must take aspirin, warfarin and other anticoagulants, the platelet count should be maintained at 50 × 109/L. 2, how to deal with cerebral hemorrhage in patients with idiopathic thrombocytopenic purpura ? How to differentiate it from common cerebrovascular accident? ITP patients with intracranial hemorrhage, the major treatment principles are the same as ordinary intracranial hemorrhage, including complete bed rest, maintain stability, keep the airway open, closely observe the vital signs, such as consciousness, blood pressure, respiration, heart rate, pupils, etc., while lowering the cranial pressure, reduce intracranial edema, can apply mannitol, high sugar and glucocorticoids (such as dexamethasone), if you can not eat, can apply nasal feeding or intravenous nutrition, maintain water-electrolyte If the patient cannot eat, nasal or intravenous nutrition can be applied to maintain water and electrolyte balance. Patients with ITP can also undergo the following therapeutic measures: 1) platelet infusion, 10-16U/time, repeated once in 4-6 hours if necessary; 2) intravenous high-dose gammaglobulin infusion, 0.4g/(kg.d), applied continuously for 5 days; 3) intracranial hemorrhage if life-threatening, emergency splenectomy can be performed. 3. How to control the indication of splenectomy in patients with thrombocytopenic purpura? Glucocorticoids are preferred in the treatment of primary thrombocytopenic purpura, and splenectomy can be considered when drug therapy fails. The indications for splenectomy in this disease are: 1) The duration of treatment is at least more than 6 months. 2) Response to glucocorticosteroid therapy but a higher dose is required for maintenance. 3) Severe life-threatening bleeding (e.g., early intracranial hemorrhage) that cannot be controlled by medication. 4)Contraindication to the application of hormones or immunosuppressive agents. 5) Good bone marrow proliferation, marked increase in megakaryocytes or combined with hemolysis, such as Enans syndrome, etc. 4. How to treat thrombocytopenic purpura? First of all, it is necessary to identify idiopathic or secondary thrombocytopenia. If it is idiopathic acute ITP, when bleeding is severe, activity should be limited, avoid trauma, concentrated platelet suspension infusion, intravenous high dose gammaglobulin, hormone. In case of fatal bleeding, simultaneous splenectomy and plasma exchange can be performed. In case of chronic ITP, treatment may include glucocorticoids, splenectomy, immunosuppressants such as vincristine, cyclophosphamide, danazol, cyclosporine A, primaquine, etc., and cocoa treatment with traditional Chinese medicine. In case of secondary thrombocytopenia, the causative factors should be removed and the primary disease should be corrected mainly, such as discontinuation of suspected drugs and control of infection. Other treatments can be given as appropriate, such as post-transfusion purpura, thrombotic thrombocytopenic purpura, Evans syndrome, etc. Glucocorticoids, plasma exchange, spleen excision and other therapeutic means can also be applied.