Chemotherapy is a kind of treatment that uses chemical drugs to kill tumor cells, inhibit the growth and reproduction of tumor cells and promote the differentiation of tumor cells, which is a systemic treatment. However, while chemotherapy kills tumor cells, it can also damage normal cells and immune (resistance) cells, so chemotherapy is a “double-edged sword” and needs to be carried out under the guidance of doctors. Chemotherapy cannot cure the tumor, but it is a powerful weapon in the treatment of tumor, and it can bring multiple myeloma into remission. The adverse effects of chemotherapy drugs, such as gastrointestinal reactions and hair loss, are gradually decreasing, while the ability to strike the tumor with precision is improving. Many multiple myeloma patients are in their seventies or eighties or older, and the principle of individualized treatment can be adopted, with individualized treatment plans designed according to the severity of the patient’s condition and physical strength. Chemotherapy is not that scary, and many senior citizens can tolerate it.