In 2010 the Lancet Neurology published the authoritative guidelines for the diagnosis and treatment of DMD, putting forward the concept of standardized treatment of DMD. With the support of the hospital and the department, we kept pace with the world’s advanced concept at the first time and started the standardized oral hormone treatment of DMD. By today, it has been nearly 5 years. Although the evidence-based medical evidence for oral hormone therapy is strong, it takes time to accumulate to see its therapeutic effects with our own eyes, to understand all aspects of it and to continuously improve it in practice. Our patients who started oral hormone therapy early on and stayed on it, with continuous follow-up, have been on treatment for more than four years. We have really seen the effect of hormone therapy, but of course, we have also seen the side effects that come with it. Dai Yi of the Department of Neurology at Peking Union Medical College Hospital has no doubt about the effectiveness of oral hormone therapy. There is no drug that can match the effect of oral hormone therapy, and its slowing down of disease progression is evident to all. The parents of a recent patient with DMD who had been treated for more than 2 years said to me, “Doctor, was our initial diagnosis wrong, are we a light BMD patient? The child has been stable for the past 2 years and is very different from other children with DMD.” After reviewing the patient’s data in our database, I told the parents with certainty, “The child is indeed suffering from DMD, and all the tests done at the time of diagnosis, whether genetic tests, muscle biopsies or muscle enzyme levels, all point to DMD, and the diagnosis is beyond doubt. The reason why he is different from other children of the same age is the result of your persistent treatment for more than two years, which is a credit to you.” The parents’ love and perseverance have held up the child differently. The reason for this doubt is that parents are able to see just their child and either stick with the treatment or stop midway, it can only be one or the other. But as a doctor, I would see a lot of different situations. For a variety of reasons, some children don’t adhere well to hormone therapy. What starts out as a similar condition is followed up a few years later with a very different story. Of course, it is important to have a scientific understanding of the effects of hormone therapy. Hormone therapy is far from a cure, and the disease will still progress slowly, but it is the best treatment we can give our children at this time.The standardized treatment of DMD is centered on oral hormones, supplemented by related therapeutic drugs. Some of these drugs slow down muscle disease from other mechanisms, some can antagonize the side effects of hormones, and some are used to treat the complications associated with DMD, thus working together to achieve the best possible outcome. In addition, treatment other than medication and regular follow-up are also important. I would like to thank Dr. Zhang Guangyu of the Department of Rehabilitation, who focuses on the rehabilitation treatment of myotonic dystrophy and guides the rehabilitation training with professional knowledge and scientific plans, so that the daily rehabilitation training can achieve twice the result with half the effort within a limited time. Thanks to Dr. Hailong Li of the Nutrition Department, who gives patients a scientific and operative diet plan. Strict implementation of the relevant diet plan can well control excessive weight gain while ensuring nutritional supply. Thanks to the strict supervision of parents and the cooperation of children, some children have lost 4 Kg of weight with the addition of hormones. thanks to Dr. Xiaoxiao Guo of the Department of Cardiology, who protects the hearts of children. He was able to perform targeted cardiac ultrasound examinations for the characteristics of the myocardial lesions of this disease, accurately assess the cardiac function and give medication according to the situation. We are very happy that the results of our collaboration have been published in SCI journals. We would like to thank Prof. Li Mei of the Endocrinology Department for adding our child to her busy schedule. The problem of osteoporosis in children with DMD treated with oral hormones through diphosphonate therapy has been well resolved. We are grateful to the patient’s organization for actively spreading the scientific concept of treatment, so that the patient’s family can keep getting “positive energy”. The most important thing to thank is the parents of the patients. Your positive attitude towards treatment is the key to the success of the treatment, and your optimistic attitude perfectly illustrates “living with the disease”. I see a long-lost smile on your faces.