According to our more than 10 years of clinical experience in treating patients with lumbar synostosis, some of the causes of lumbar synostosis are mainly due to sterile inflammation, which is located in the nucleus pulposus of the intervertebral disc. Normal intervertebral disc has peripheral annulus fibrosus and central nucleus pulposus, the tissue structure is like a squashed egg, protein is like annulus fibrosus, yolk is like nucleus pulposus, protein rupture, yolk overflowing, infiltration of the sciatic nerve behind the intervertebral disc, and low back pain. So the lumbar pain produced by lumbar synostosis is aseptic inflammation! Xing Wenhua, Department of Cervical Spine Surgery, The Second Affiliated Hospital of Inner Mongolia Medical University There are also some cases of lumbar and leg pain caused by mechanical compression of the nerve root due to disc herniation, and these patients need surgery if their pain cannot be relieved by conservative treatments such as bed rest and physical therapy.