Bowens disease (Bowens disease), a relatively rare early squamous carcinoma in situ of the skin, mostly develops above 45 years of age and is more common in males than females, with the main clinical manifestation of chronic, asymptomatic, scaly plaques. Some patients are accompanied by malignant tumors other than skin. Surgical excision is a reliable treatment, and follow-up is needed after healing to prevent recurrence and complication of other malignant tumors. Bowen’s disease is a squamous carcinoma of the skin in situ with an unknown etiology. Multiple lesions may be related to exposure to arsenic agents or visceral tumors, and it occurs in patients over 40 years of age, more in men than in women. Long-term sunlight exposure may be an important predisposing factor, and some patients are associated with arsenic exposure. Other factors such as long-term exposure to coal tar, viral infection, friction or injury can be triggers. Early diagnosis of the disease and timely surgical excision is the key to treatment. Bowen’s disease is a kind of early carcinoma in situ of the skin, which occurs in the head, neck, hands, trunk, buttocks, anus, mucous membrane of the genital tract, oral mucous membrane, nail beds, etc.; the most common place is the head and neck (the rate of the disease is 44%~54%). The disease is a disease of adults, the age of onset is from 20 to 90 years. Vulvar Bowen’s disease is a type of vulvar carcinoma in situ, which develops in association with sexual intercourse and chlamydia, HPV 16, 18, 30, 31 and 33 infections. This disease is not very rare, a city in China has found two cases of this disease. Diagnostic points 1, mostly occur in middle age and above. 2, the damage can occur in any part of the skin or mucous membranes, with the trunk, limbs most common. 3, the lesions are initially erythematous, round or oval, gradually expanding, irregular in appearance, often with keratinized scales on the surface. The boundary of the lesion is clear, and it may be slightly elevated, and there are generally no conscious symptoms. 4, the onset of insidious, chronic course. 5. Ulcers appear in the skin lesions, which is often a sign of invasive growth. 6.Mostly single, there are also multiple or generalized. 7, part of the multiple occurrence can be caused by long-term exposure to arsenic, Figure 6, can also be combined with visceral tumors. 8, histopathology shows that the whole layer of epidermis keratinocyte arrangement disorder, nuclear size is not equal, irregular, deep dye. Common poorly keratinized cells, abnormal nuclear schizophrenia and multinucleated giant cells, some cells cytoplasmic staining was vacuolated, similar to Paget cells. The basement membrane band is intact. Treatment points Surgical excision, electrocautery, cryotherapy and radiotherapy may be used as appropriate. 1, preferred surgical treatment (Mohs surgery is the best); 2, lesions smaller, available cryotherapy; 3, not suitable for surgical treatment of patients and parts of the feasibility of superficial X-ray treatment; 4, local chemotherapy, suitable for elderly patients or inappropriate for surgical parts, commonly used 5% 5-fluorouracil ointment for external use. Tips: Bowen’s disease is a kind of early skin cancer, as long as you can go to the regular hospital in time and take correct treatment, the prognosis is good. One should go to hospital regularly for comprehensive examination to observe whether there is recurrence or complication of malignant tumor. Long-term exposure to sunshine should be avoided, straw hat should be worn for outdoor work, and contact with arsenic-like substances should be avoided. 1.Cured: after treatment, the tumor disappears completely without complications and recurrence; 2.Improved: after treatment, the tumor basically disappears, need to continue to observe and follow up; 3.Not cured: after treatment, the tumor has not disappeared, or there are obvious complications.