Lymphoproliferative lesion treatment includes radiation therapy, cryotherapy, and chemotherapy. Lymphoproliferative lesions can occur in the orbit, on the surface of the eye, and within the eye. Previously, it was thought that lymphoproliferative lesions were either benign reactive lymphoid hyperplasia or malignant lymphoma, and it is now believed that there are major difficulties in the differential diagnosis of these diseases. Lymphoproliferative lesions of the conjunctiva are clinically difficult to distinguish between benign and malignant and require biopsy to confirm the diagnosis. Treatment is by radiotherapy or cryotherapy. In addition, a whole-body CT scan is needed to exclude lymphoma in other parts of the body. Malignant lymphomas of the eye are often called reticulocytosarcomas and are mostly bilateral or can be solitary. It is easily misdiagnosed as uveitis, and further examination may reveal a retinal pigmented intraepithelial mass. Vitreous biopsy is often required to make a definitive diagnosis, and patients often require radiotherapy and a systemic evaluation by an oncologist. Most malignant or systemic lesions require radiotherapy in combination with chemotherapy. Radiotherapy helps to confine the tumor. Proliferative lymphoid tissue lesions are recommended to be treated as early as possible.