1.Tumor-related etiology: tumor can cause pain in various ways. Pain caused by direct infiltration of tumor is most commonly caused by bone metastasis, compression of nerve or infiltration of nerve destruction. 2.Pain caused by treatment: Pain caused by anti-cancer treatment mainly comes from three aspects: surgical treatment, chemotherapy and radiotherapy. In addition, some examination means taken in the diagnosis of tumor can also cause pain to some extent, such as lumbar puncture to take cerebrospinal fluid, blood specimen, angiography, endoscopy and tissue biopsy, which are mainly caused by primary injury, inflammation or reflex activity. In addition, radiotherapy and chemotherapy suppress the immune system, making patients vulnerable to viral, bacterial and fungal infections causing pain, such as herpes zoster, chickenpox, etc. 3. Comorbidities not related to tumor, pain can be caused by concurrent benign pain, which can be aggravated by anti-cancer treatment or tumor progression, such as disc prolapse, osteophytes, osteoarthritis, rheumatism, rheumatoid, migraine, etc. Tumor treatment emphasizes early diagnosis and early treatment. In addition to the active radical treatment, the control of associated pain should not be neglected, especially when the tumor cannot be cured and pain has become the main pain, the tumor should be actively treated to reduce the patient’s pain, maintain the personality of the tumor patient and improve the quality of life of the tumor patient. Tumor treatment methods can be divided into two categories: one is anti-cancer treatment to eliminate the pathophysiological mechanism that produces pain, and the other is treatment to change the pain perception. For tumor and associated pain, anti-cancer methods such as surgery, radiotherapy and chemotherapy should be used as much as possible to remove tumor and eliminate pain. When choosing specific analgesic methods, the following matters should be actively considered: whether it leaves sequelae, side effects, less trauma, simple methods, whether it can provide long-term pain relief, whether it can restore patients’ daily life, and whether it is effective for recurrent pain. Of course, there is no such ideal analgesic method yet, so it is necessary to choose the analgesic method suitable for each patient and comprehensive treatment, and should be accompanied by enthusiastic nursing, care and encouragement from colleagues and family, so that patients can enhance their confidence to overcome pain. 2.Chemotherapy: pain relief is achieved by reducing the volume of tumor. 3.Surgical treatment: remove the tumor, remove the cause of the disease, and the pain will disappear naturally. 4.Pharmacotherapy: For tumors, the World Health Organization recommends a three-step pain relief method, that is, first use non-morphine analgesics, if it cannot relieve pain, then use weak morphine analgesics, and finally rise to strong morphine analgesics. 5.Neural destruction: The nerves are killed by anhydrous alcohol or phenol glycerin to achieve permanent pain relief, which is generally used for tumors where painkillers are ineffective. 6.PCA: It is popular at home and abroad, i.e., patient-controlled analgesia. By placing catheters in veins, epidural cavity, subcutaneous and other parts, pain medication will be pumped into the body according to the patient’s own needs to achieve pain relief. 7.Prognosis: Through the above methods, most of the tumor patients can relieve or remove the pain, which greatly improves the quality of life of patients during their survival.