Although gastric ulcers are a common disease, most of them can be cured. The two major causative agents of gastric ulcers are H. pylori infection and damage from NSAIDs. Inflammation of the mucosa occurs after H. pylori infection, and the ability to resist damage is diminished, and the role of physicochemical damage factors is relatively enhanced. Aspirin and NSAIDs can directly damage the mucosa and can inhibit mucosal regeneration and repair functions. In both cases, mucosal damage is not self-repairing. Minor damage can gradually worsen and become ulcers. For the treatment of gastric ulcers, the presence of H. pylori infection and a history of aspirin and NSAID use should be evaluated first. If H. pylori infection is present, the maximum possible eradication of the bacteria is sought. The ulcer can be cured. If taking aspirin or NSAIDs, discontinue as much as possible if other conditions allow. If discontinuation is not possible, eradicate H. pylori as much as possible because, in the presence of H. pylori infection, mucosal damage and ulcer development caused by aspirin or NSAIDs are significantly more likely to occur in the absence of bacterial infection. Of course, in patients with multiple coexisting diseases or discontinuation of aspirin, etc. may not be realistic, and in such cases strong gastric acid inhibiting agents such as lazoles need to be applied continuously, and mucosal protective agents can also be added together to maintain treatment for ulcer healing or to reduce the chance of serious complications such as bleeding and perforation. Therefore, there are many more mature treatments for gastric ulcers and most patients can be cured.