Elliott et al. of Riverside Methodist Hospital in Ohio completed a study on quality of life in patients with epilepsy and published the results in a recent issue of the journal Epilepsy Research. The clinical literature suggests that epilepsy affects quality of life differently in male and female patients. However, previous studies on gender differences in quality of life have mainly examined bio-biomedical factors rather than psychological and sociological factors. This study applied data from the Canadian Community Health Survey to compare the subjective and objective quality of life of adult epileptic and non-epileptic patients by gender using a biopsychosocial model. After correction for biomedical variables, all scores on quality of life, except the Health Utility Index (HUI3), were lower than before correction for biomedical variables. Men with epilepsy were more likely to obtain HUI3 scores of 0.70 and above than non-epileptic men. Therefore, treatment of patients with epilepsy should consider the patient as a whole person, rather than being concerned only with the disease itself. Gender differences should be considered when objectively evaluating quality of life.