The term “closure” was directly translated from the former Soviet Union in the 1940s and originally meant to block the adverse injurious stimuli from the lesion to the central nervous system by injecting a local anesthetic (the newly invented anesthetic at that time was procaine, which is no longer used clinically) proximal to the lesion site to break the resulting painful The vicious circle of pain that results from this is broken by “sealing” the adverse stimuli locally, thus facilitating the relief of pain symptoms and the natural recovery of the disease. This implication emphasizes the role of the “nerve reflex” that was popular at the time (the famous Pavlovian dog nerve reflex was also discovered in that era). Clinicians were always quick to apply advanced theoretical findings to the clinical treatment of their patients. After the “closure” treatment was used in the clinic, doctors made two improvements: first, local anesthetics were injected directly into the inflammatory site of the lesion, instead of the proximal part of the lesion, which provided more direct and better pain relief; second, corticosteroids were added to the injected solution to achieve pain relief by exerting their powerful anti-inflammatory effect. The second is to add corticosteroids to the injected solution to achieve the effect of stopping pain and treating the symptoms by exerting its powerful anti-inflammatory effect. Later, in order to pursue “one shot”, some doctors increased the concentration of local anesthetics, increased the dose of hormones, and increased the volume of the injected solution. Obviously, the therapeutic effect was better, but the side effects of the drugs, especially hormones, began to appear widely in patients who had repeated injections for a long time. Long-term high-dose injections of corticosteroids can induce the development of hypertensive disorders, diabetes, peptic ulcers and osteoporosis, as well as other adverse effects such as obesity and endocrine disorders. Moreover, these complications can have long-lasting consequences, causing long-term suffering to patients and their families. Therefore, people often talk about “closed” and change, but also has its own reasons. With the development of medical science today, is it not possible to obtain good treatment results while minimizing side effects? The answer is, yes! The “local injections” that our pain doctors are doing now use very low concentrations of local anesthetics and safe doses of glucocorticosteroids in the solution, and more precise injection techniques reduce the amount of solution used, so the associated side effects are significantly reduced. For example, in the last 10 years of injection treatment in our pain center, there has been no significant hormone-related side effects or long-term adverse reactions in any of our patients. In addition, depending on the patient’s condition, we also inject other drugs such as medical ozone and sodium hyaluronate, which have nothing to do with “closure”. Therefore, the modern treatment method is called “injection therapy”, not “closure”. Compared with oral drugs, injectable drugs have a more precise scope of action, stronger local therapeutic effect and less systemic side effects, and are the preferred non-surgical treatment for neck, shoulder and lumbar pain.