Only 5-15% of thyroid nodules are malignant nodules and require surgery. For the majority of benign thyroid nodules, treatment is only needed if they are large, have symptoms of pressure or affect their appearance. However, there is a lack of clear and effective oral treatment medications, and surgical treatment is often required. For benign thyroid nodules that are unwilling to undergo surgical removal, or that recur after surgery, or where surgery is risky, minimally invasive radiofrequency ablation is an effective, minimally invasive treatment. Radiofrequency ablation of thyroid nodules is a treatment that is guided by ultrasound, where a radiofrequency electrode needle is placed into the nodule by percutaneous puncture, and a high-frequency alternating current passes through the tip of the electrode needle, causing the water molecules and ions in the nodule tissue to heat up by shock and friction, which raises the temperature in the local tissue cells, thus causing protein denaturation and coagulation necrosis of the nodule cells to occur rapidly, followed by self-absorption to achieve the treatment purpose of shrinking or clearing the nodule. That is to say, without the use of surgery, the principle of physical action to achieve similar results as open surgery. The advantages of radiofrequency ablation of thyroid nodules are: 1) minimally invasive, with a low incidence of complications; 2) avoidance of surgical skin scarring; 3) minimal damage to the thyroid gland, especially to thyroid function; 4) high safety of re-treatment of new and re-occurring nodules. The disadvantage is that it takes time for the nodules to shrink and disappear, usually half in 1-3 months, and the maximum effect is achieved after half a year or one year. The Department of Endocrinology of Guangdong Provincial People’s Hospital, through strict staff training, academic exchanges at home and abroad, and determination of standardized treatment process and overall treatment plan, formally passed the third category of medical technology evaluation of Guangdong Provincial Medical Association in 2014, and became the first endocrinology specialty in China to routinely and standardizedly carry out ultrasound-guided radiofrequency ablation of benign thyroid nodules after strict audit and approval. At present, radiofrequency ablation of thyroid gland is applied to the following patients: (1) progressive or symptomatic benign nodules with benign cytological/histological pathological examination by two fine-needle/coarse-needle aspiration, nodules with maximum diameter <5cm; (2) recurrent benign nodules after surgery; (3) palliative conservative treatment of malignant thyroid nodules with recurrence or metastasis after surgery; (4) no serious disorders of coagulation mechanism and cardiopulmonary diseases; (4) voluntary signing of informed consent for ablation treatment. (5) Benign nodules that are not suitable or not considered for surgical treatment. In the past year, our endocrine specialty has performed fine mobile ablation of benign thyroid nodules under ultrasound guidance in more than 40 cases of patients with benign thyroid nodules using special radiofrequency ablation equipment for thyroid and electrode needles, and all of them were successfully treated in one visit. The treatment effect is remarkable and safe. The main side effects are transient local swelling, pain and skin ecchymosis.