Fungal keratitis is one of the most dangerous diseases developed in the 1950’s. If not diagnosed and treated promptly, it can lead to corneal perforation, blindness, and in more serious cases, ocular extraction. Fungal keratitis was first reported by Leber in 1879, and since the 1950s, the incidence of fungal keratitis has increased year by year due to the widespread use of hormones and antibiotics, the increased use of corneal contact lenses, and the improvement in the diagnosis and treatment of the disease. In the past decade, the incidence of fungal keratitis has increased significantly in China, mainly related to the widespread use of broad-spectrum antimicrobials and corticosteroids, or the long-term wearing of corneal contact lenses and the application of immunosuppressive agents. Fungus is a conditional pathogen, and trauma remains the first causative factor of fungal keratitis in China, with the number of cases of vegetative trauma leading to morbid blindness increasing year by year. To date, more than 70 species of fungi have been found to cause corneal infections. The main fungal species causing corneal infections vary greatly from region to region. Developed regions and colder climates (such as the northern United States and the United Kingdom) the most common pathogenic species is Candida albicans (31.6% to 48.8%); developing countries and warm or hot climates (such as South Florida, India, Nigeria, etc.) is mainly Fusarium and Aspergillus (Aspergillus 12% to 47%, Fusarium 16% to 62%), in China, Guangdong, Henan, Hebei and Shandong areas show that fungal keratitis pathogenic species to Fusarium and Aspergillus, most of which is the first causative agent Fusarium, accounting for 28% to 65%; followed by Aspergillus, accounting for 11% to 49%; 3rd to 4th are Penicillium (3.6% to 11.6%) and Aspergillus (1.2% to 13.1%). Schwab believes that filamentous fungal keratitis mostly occurs in healthy people, whose susceptibility factors are trauma, especially vegetative trauma, local The application of hormones increases the likelihood of development, but is not necessary; the main susceptibility factor for Candida albicans keratitis is long-term corneal epithelial ulceration. Penetrating keratoplasty, wearing therapeutic soft contact lenses, and topical application of hormones promote the proliferation of the fungus. Histopathological characteristics analysis: different fungi their own infection characteristics and growth mode due to the adhesion of the causative fungus to the cornea, the damage to the corneal tissue is also different, the common features are the direct destructive effect of the fungus on the corneal tissue, the infiltration of a large number of neutrophils in the corneal tissue. The release of phospholipase A and lysophospholipase by the fungus (Fusarium) destroys the lysophospholipase of the host cell membrane, making the corneal tissue often coagulative necrosis, constituting a pathological change unique to fungal corneal infections. Inflammatory cells accumulate in the anterior chamber, forming an anterior chamber pus accumulation. It is speculated that the anterior chamber pus accumulation that causes FK is not the result of direct fungal invasion, but may be a sterile inflammatory response to fungal toxins stimulating the uvea. The main pathological changes of keratoconus are extensive purulent inflammation, massive neutrophil infiltration, coagulative necrosis of the corneal stroma and swelling of collagen fibers, and the formation of small, isolated abscesses near the lesion, with polymorphonuclear leukocytes forming a granulomatous reaction around the fungus in the late stage of the disease. The pathogenesis of fungal keratitis can be summarized as the following four points: (1) direct destruction of corneal tissue by fungi and toxins; (2) the destructive effect of neutrophil enzymes; (3) immune factors: in the process of lesions, fungi and toxins or degenerative corneal tissue stimulate the body to produce antibodies, antigen-antibody complexes deposited in the corneal tissue, resulting in neutrophil accumulation and fungal brewing together into fungal keratopathy; (4) Reduced immunity, especially cellular immune function, may contribute to the development of keratoconus fungal disease. It is the only ophthalmic antifungal eye drops recognized by the United States Pharmacopoeia, the first-line ophthalmic antifungal drug recommended by many experts; the first choice of treatment to kill Candida, Aspergillus and Fusarium in the eye. The vast majority of patients are farmers, although it can occur throughout the year, but mainly concentrated in the agricultural summer and autumn harvest season. Fungal keratitis 1. Develop good hygiene habits, wash your hands regularly and cut your nails often. 2, do not wear contact lenses for a long time; be careful when replacing contact lenses. 3, the same as the prevention of acute conjunctivitis, mainly to cut off the source of infection and pay attention to eye and hand hygiene. 4.Prohibit patients from bathing and swimming in public places. 5, the treatment is mainly local medication, medication internal and acupuncture also have a certain role. 6, eat more food and fruit with cold and clear heat and fire, such as wild rice, winter melon, bitter melon, fresh root, sugar cane, bananas, watermelon and so on.