Coughing eye pain may be caused by cold, keratitis, conjunctivitis and other diseases, the specific situation needs to be determined according to the patient’s clinical manifestations and relevant examinations, and treated symptomatically under the guidance of a professional doctor. 1. cold: usually due to infection by pathogenic microorganisms, which may lead to violent coughing and increasing pressure in the eye chamber during coughing, which may result in eye pain, accompanied by high fever, headache and weakness. Patients can take targeted oseltamivir phosphate, amoxicillin, and ambroxol hydrochloride under the guidance of a doctor for treatment. 2. Keratitis: Mostly due to the weakened defenses of the cornea, external or endogenous pathogenic factors invade the corneal tissue, usually manifesting as eye pain, photophobia, tearing, eyelid spasm, and other undesirable symptoms, which may lead to coughing eye pain. Patients can use cefdinir and tobramycin as prescribed by the doctor for treatment, and can also apply fluconazole drops for treatment; 3. Conjunctivitis: manifests as foreign body sensation, burning sensation, heavy eyelids, and increased secretions in the eyes, which may lead to a condition of coughing eye pain. Patients can be treated with ganciclovir eye drops and levofloxacin eye drops under the guidance of a doctor.