Diabetic patients have been taking metformin and glimepiride, now fasting blood glucose 13mmol/L, indicating that the effect of blood glucose control is poor, need to change the drug or inject insulin treatment, should strictly comply with the doctor’s instructions for medication. Glimepiride is a sulfonylurea hypoglycemic drug, the main mechanism of action is to stimulate the pancreas to secrete insulin; metformin belongs to the class of biguanide hypoglycemic drugs, which can inhibit hepatic glucose output, increase the utilization of glucose by peripheral tissues, and increase the sensitivity of insulin. For diabetic patients, the goal of glycemic control is generally in the fasting blood glucose 4.4mmol/L ~ 7.0mmol/L, fasting blood glucose 13mmol/L indicates that the blood glucose control is not good, it may need to change the drug or inject insulin treatment. Patients should not take or stop medication on their own, and it is recommended that patients seek medical attention in a timely manner and under the guidance of a doctor.