Vasculitis is a diffuse lesion of blood vessels, and Kawasaki disease is a coronary artery lesion that occurs after inflammation of the coronary arteries, and there is a certain difference between the pathogenesis of the two. 1. vasculitis: is caused by a variety of etiological factors of a kind of inflammatory changes in blood vessels, can be manifested as necrosis of small arteries, belongs to a kind of autoimmune disease, small arteries throughout the body can be involved, such as small blood vessel involvement can be manifested as purpura, pulmonary blood vessel involvement can be manifested as chest tightness hemoptysis, renal blood vessel involvement can be hypertensive, and can’t be completely cured. 2. Kawasaki disease: also manifested as inflammatory changes in blood vessels, mainly violating the coronary arteries, infection is the main triggering factor, some patients can appear coronary artery aneurysm, but rarely appear systemic changes, does not belong to the systemic vascular inflammatory changes. Early active treatment can be completely cured, some patients will be left with coronary artery aneurysm-like lesions. Vasculitis and Kawasaki disease are two completely different diseases, patients with related diseases should go to the hospital in time, under the guidance of physicians.