The most important treatment concern for epilepsy patients is when to reduce and discontinue medication. This is because 80% of epilepsy patients have their seizures controlled with medication, and 60% of these patients remain seizure-free after stopping medication. What should epilepsy patients pay attention to when reducing and stopping their medication? 1. Patients should be completely seizure-free for more than 2-5 years under medication before they can consider stopping medication. 2. Before deciding to discontinue medication, the risk of recurrence after discontinuation must be taken into account, therefore, a discontinuation evaluation should be performed before discontinuing medication. The risk of recurrence is significantly higher in the following cases, those with consistently abnormal EEG, more seizure types, significant neuroimaging abnormalities and significant neurological deficits. 3. The prognosis varies between syndromes, e.g., in benign syndromes in children, discontinuation can be considered after 1-2 years without seizures; in juvenile clonic epilepsy, even after 5 years without seizures, the recurrence rate is high after discontinuation; LG syndrome may require longer treatment. 4. The discontinuation process should be done slowly and may last for several months or even more than a year. 5. In case of combination therapy, only one drug should be reduced at a time, and if there is still no seizure after at least 1 month after reducing one drug, then consider reducing the second drug. 6. If a seizure occurs during drug reduction or discontinuation, the drug should be restored to the dose before the seizure.