Tennis elbow is also known as lateral humeral epicondylitis, lateral elbow pain syndrome, commonly known as tennis elbow. It is a disease caused by acute trauma, chronic strain or wind, cold or dampness, resulting in local qi and blood stagnation and stagnation of the ligaments and veins, with limited pain in the lateral epicondyle of the humerus as the main symptom. Patients with tennis elbow are mainly characterized by wrist extension and forearm rotation dysfunction, mostly seen in adults who need to repeatedly perform forearm rotation and wrist extension activities. The pathology of tennis elbow is based on tendon degeneration rather than inflammation. Tennis elbow requires a combination of therapeutic measures, and most patients can be treated non-surgically with good results. Commonly used treatments include health education, local physiotherapy and local closed injection therapy. The application of hormonal therapy has been increasingly questioned in recent years. The use of local injections of botulinum toxin type A, autologous blood platelet-rich plasma, and sodium glacialate has opened up new ideas for the non-surgical treatment of tennis elbow. To avoid injecting the drug into the tendon, ultrasound-guided injections are recommended. A common adverse effect of botulinum toxin injections in tennis elbow is weakness of the wrist and finger extension muscles after the injection. Botulinum toxin type A injections were used to treat tennis elbow. When botulinum toxin type A was injected into the radial short extensor carpi radialis muscle 2 transverse fingers distal to the lateral epicondyle of the humerus, patients experienced significant relief of elbow pain and improvement in elbow function. The study showed that the local lactate concentration in the lateral epicondyle was significantly lower than before the treatment. Therefore, after botulinum toxin treatment, the blood flow within the muscle increased, and the aerobic metabolic reaction occurred locally in the external epicondyle, which reduced the lactic acid production caused by anaerobic metabolism and alleviated the elbow joint pain. Therefore, botulinum toxin type A injections can be used to treat patients with refractory tennis elbow (external humeral epicondylitis) in whom conservative treatment is not effective.