Mastocytosis is not a single disease clinically or pathologically, but rather a combination of changes with a variety of names, including cystic hyperplasia of the breast, lobular hyperplasia, and fibrocystic mastopathy. Clinical manifestations often include breast pain or benign nodules alone or simultaneously, and can fluctuate with the menstrual cycle. Even in women without any breast symptoms, the corresponding pathological manifestations are present in up to 90% of the population. It is now believed that breast enlargement does not necessarily represent a pathological condition and that the vast majority of these may be physiological in nature. The pathogenesis of mastocytosis is unclear and may be related to endocrine dysfunction, or incomplete restoration of the breast during the menstrual cycle. There is no definite relationship between this disease and breast cancer, and women with hyperplastic manifestations do not have an increased risk of developing breast cancer in the absence of other risk factors. The disease usually does not require treatment. A few patients with a history of more than 6 months and more severe symptoms may consider some medication for symptom control. Patients need to pay attention to adjust their emotions and avoid excessive stress, which may improve naturally after some time. However, if a gradually increasing swelling is palpated or if pathological manifestations such as plasma or bloody overflow appear, a hospital visit should be made.