In addition to affecting the respiratory system, some patients with pneumonia caused by novel coronavirus infection also show signs of liver damage to varying degrees, the pathogenesis of which is still unclear. The receptor for the novel coronavirus to enter human cells is the ACE2 protein, and the liver damage in patients may be due to direct binding of the virus to ACE2-positive bile duct cells, which leads to bile duct dysfunction; it may also be due to toxic side effects caused by therapeutic drugs that are not due to direct binding of the virus to hepatocytes.