The application of medicine to treat “tumors” has been recorded since the beginning of written history. In China, there were “ulcer doctors” who specialized in dealing with lumps and ulcers since the Zhou Dynasty. However, tumors have been regarded as a rare disease for a long time. The discovery of microscope in modern times positioned tumor as “local cellular malignancy” and surgery became the main treatment. In recent years, the incidence of tumor has increased rapidly and become a serious threat to the health and life of the population. People also gradually realize that tumor is a systemic disease. Comprehensive treatment is the key to improve the efficacy and prognosis for most of the malignant tumor patients. Currently, the treatment of tumor is in a period of significant change, and evidence-based medicine, standardization and individualization of treatment have become the direction of our efforts. Integrated treatment is an important part of standardized treatment. The so-called integrated treatment is to provide the best treatment plan for patients in a rational, planned and individualized way by using the existing treatment means, with the aim of improving the quality of life and prolonging the survival of tumor patients. The main treatments for malignant tumors include surgery, radiotherapy, chemotherapy, endocrine therapy, molecular targeted therapy and Chinese herbal medicine. Comprehensive treatment is not a simple list of all the treatment methods, but a comprehensive treatment with clear purpose, basis, plan and reasonable. Pre-operative radiotherapy has the advantages of shrinking the tumor through radiotherapy, reducing the contamination of cancer cells in the surgical field and decreasing the spread; the disadvantage is delaying the surgery. The more affirmative values include head and neck cancer, lung apical cancer, etc. 2.Intraoperative radiotherapy has the advantage of irradiation under direct vision, and the disadvantage is that it can only be irradiated once. Intraoperative radiotherapy for gastric cancer is of more definite value. 3.Postoperative radiotherapy has the advantages of clear diagnosis and pathological support; the disadvantage is that postoperative tumor blood transport is poor and the residual cancer cells are insensitive to radiation due to lack of oxygen, so postoperative radiotherapy is often needed for breast and soft tissue sarcoma. For example, for breast-conserving treatment of early-stage breast cancer, the primary lesion is removed surgically and the subclinical lesions in the breast are controlled with moderate dose radiotherapy, achieving the same efficacy as modified radical surgery, and the intact breast can be preserved with good cosmetic effect. Chemotherapy or endocrine therapy can be given afterwards. Secondly, combined radiotherapy and chemotherapy are often used to control localization with radiation therapy and metastatic spread with chemotherapy. Combined radiotherapy and chemotherapy have achieved better results in the treatment of small cell lung cancer and lymphoma. In addition, there are many other comprehensive treatment options such as combining endocrine therapy, molecular targeted therapy, and Chinese herbal medicine treatment. In conclusion, our treatment principle is to make full use of the existing treatment methods and provide patients with individualized and optimal treatment plans without increasing their pain. To improve the survival rate and reduce the disability rate so that tumor patients can benefit to the maximum extent.