The exact maximum life expectancy for essential thrombocythemia cannot be determined and will vary depending on the individual’s health and condition. If treated promptly, it does not usually affect normal life expectancy. 1. Primary thrombocythemia has little effect on life expectancy if there are no complications such as blood clots and embolism. 2. However, in some patients, the evolution of the disease over several years or even longer, transforming into myelofibrosis or leukemia, can severely shorten survival. Patients with primary thrombocythemia who receive effective and appropriate treatment (hydroxyurea, interferon, aspirin) and have their platelet counts return to normal, then the difference in life expectancy compared to healthy individuals is not significant. When treating the disease, patients should choose the appropriate treatment according to the doctor’s advice and should not use medication on their own.