Infertility refers to women of childbearing age who have had normal sexual intercourse without contraception after marriage and have lived together for two years without conceiving, or who have had a pregnancy and have not conceived for two consecutive years without using contraception. There are many causes of infertility, with ovulation disorders and tubal factors being the most common. In recent years, more and more pituitary adenomas have been detected with the advancement of screening technology, and the endocrine disorder caused by hyperprolactinemia, which eventually leads to “amenorrhea, lactation and infertility”, is getting more and more attention. So what exactly is a pituitary adenoma? Pituitary tumor is a benign tumor composed of adenopituitary cells and is a common intracranial tumor, accounting for about 10%-15% of intracranial tumors, and its harmful effects are mainly manifested in the following aspects: ① Excessive secretion of pituitary hormones causes metabolic disorders and organ damage, such as amenorrhea, lactation, acromegaly, etc.; ② Tumor compression causes low pituitary hormones and low function of the corresponding target glands; ③ Compression of the pterionic saddle area and surrounding (3) Compression of the saddle area and surrounding structures such as optic cross, optic nerve, cavernous sinus, hypothalamus, triple ventricle and even the frontal lobe, temporal lobe and brainstem, resulting in serious impairment of the corresponding functions. Pituitary tumors are classified according to the hormone they secrete into growth hormone (GH) adenomas, prolactin (PRL) adenomas, adrenocorticotropic hormone (ACTH) adenomas, thyroid stimulating hormone (TSH) adenomas, gonadotropin (GnH or FSH/LH) adenomas, and nonsecretory adenomas. Different adenomas have different symptoms, the most common being PRL adenoma and GH adenoma. What is “amenorrhea-lactation-infertility”? It is a group of associated syndromes that are the main clinical symptoms of hyperprolactinemia. The most common cause of hyperprolactinemia is pituitary prolactin adenoma. Therefore, once the manifestation of amenorrhea, lactation and infertility occurs, it is recommended that you go to a large hospital with conditions and see a doctor in the endocrinology, neurosurgery or gynecology clinic. The doctor will arrange for you to have your serum prolactin (PRL) and other hormones checked, and if the PRL result exceeds the normal value, after excluding the influence of drugs and other factors, you can choose to further check the MRI-enhanced scan of the saddle area, which will basically clarify whether you If the PRL result exceeds normal, you can choose to have an MRI-enhanced scan of the saddle area to clarify whether you have a pituitary tumor. When a pituitary tumor is diagnosed, many patients are confused about the treatment options: what is a reasonable treatment? Pituitary adenomas are usually benign tumors with promise of cure. The ideal goals of treatment for pituitary adenomas are: (1) to eliminate or reduce the compressive effect of the mass and prevent its recurrence; (2) to control hormone levels in the normal range; and (3) to alleviate complications due to high hormone secretion levels, especially cardiovascular, pulmonary and metabolic disorders. The traditional treatments for pituitary prolactin adenoma include internal medicine and surgery. The most familiar drug is bromocriptan, which can effectively control the symptoms caused by hyperprolactinemia in most patients and also has a certain effect on other adenomas, but its disadvantage is also obvious, that is, there is a possibility of recurrence when the drug is stopped; also, from the surgical point of view, the application of this drug can cause the tumor to shrink and become tough and hard, which increases the possibility of future In addition, from the surgical point of view, the application of this drug will cause the tumor to shrink and harden, which will make it more difficult to use surgical treatment later. The surgical treatment of pituitary adenoma is the mainstream treatment at present, and it is also a popular research content in neurosurgery, and its development is the most rapid in the field of neurosurgery. Specific surgical approaches are generally divided into two categories: open surgery and transsphenoidal approach surgery. Transsphenoidal surgery is a non-cranial approach to reach the pituitary tumor through an anatomical structure called “pterygoid sinus” under the pituitary gland from the nasal cavity or under the lip of the mouth. Compared with craniotomy, it has the advantages of direct tumor exposure, no need to shave the hair and open the skull (cover) bone, no change in craniofacial appearance, less trauma and danger, good curative effect and high curative rate, which is the preferred procedure adopted by most experts. Pituitary adenomas suitable for transsphenoidal surgery include: 1) pituitary microadenomas (<1 cm in diameter); 2) adenomas invading the pterygoid sinus; 3) pituitary adenomas extending suprasellarly but not parsellarly. Although transsphenoidal pituitary tumor surgery seems to be simple, it is not easy to do it well because of the special characteristics of pituitary tumors and the high diagnostic and therapeutic equipment requirements for transsphenoidal approach surgery, especially the basic neurosurgical skills of the surgeon. In conclusion, the possibility of pituitary tumor should be thought of for patients with infertility. Once pituitary tumor is diagnosed, it is crucial to choose a medical unit with good reputation and strong technical strength and experienced and skilled surgeons. The Pituitary Tumor Specialized Group of the Department of Neurosurgery of Shengjing Hospital of China Medical University is dedicated to the standardized treatment of pituitary tumors. In terms of diagnostic technology, the latest and powerful MRI supported by the latest generation of software is used to increase the accuracy of diagnosis; the high-performance German Zeiss stepless zoom operating microscope is applied during surgery, which greatly improves the tumor identification and total resection rate during surgery, and the patient's postoperative reaction is less severe; of course, it is more important to have a good knowledge of pituitary tumors. What is more important is that we have experts who have specialized in pituitary tumor research and rich clinical experience, and carry out transsphenoidal approach pituitary tumor resection surgery earlier, and the number and level of treatment are among the leading in China. All these are important guarantees for patients to obtain ideal results.