Multidrug-resistant bacterial infection is a phenomenon in which a pathogenic microorganism, which is resistant to three or more classes of antimicrobial drugs, develops simultaneous resistance. Most of the ideal treatment can be cured, a very small number of unsatisfactory treatment can not be cured, can lead to infectious shock or sepsis, etc.. I. Ideal treatment: 1, methicillin-resistant Staphylococcus aureus: mainly to aminoglycosides, macrolides, fluoroquinolones will be resistant to vancomycin, while vancomycin is more sensitive, if it is the choice of sensitive vancomycin treatment, the majority of patients can be cured; 2, anti-carbapenem dilute Enterobacteriaceae: Gentamicin, cephalosporin, chloramphenicol, erythromycin can be resistant to drugs, but polymyxin, tigecycline, Meropenem and other drugs can treat carbapenem-resistant Enterobacteriaceae, general patients can be cured. Second, the treatment is not ideal: the emergence of hospital-acquired vancomycin enterococci lung infections, mainly on aminoglycosides, penicillins, fluoroquinolones, cephalosporins, vancomycin drugs, there are varying degrees of resistance phenomenon, thus increasing the difficulty of the use of antibiotics, in the general antimicrobial drug therapy is not ideal, the patient should be re-do bacterial culture and drug sensitivity test, according to the results of drug sensitivity to re- Select antibiotic treatment. If the patient’s body immunity is severely reduced, multiple organ failure, the patient’s condition is serious, life-threatening, and may not be curable.