More than half of our patients with cirrhosis are caused by the hepatitis B virus. The persistence of the virus, moderate to severe liver necrosis inflammation, and fibrosis are the main causes of the evolution of hepatitis B into cirrhosis and even liver cancer. If cirrhosis occurs, it requires comprehensive treatment, the most important of which remains antiviral treatment for the cause of the disease, hepatitis B virus replication. The goals of antiviral treatment for cirrhosis can be divided into three levels: the basic goal is undetectable hepatitis B virus DNA and serological conversion of HBeAg-positive patients and normalization of liver function; the medium-term goal is liver fibrosis and even cirrhosis reversal; the final goal is to prevent liver cancer, prolong life expectancy and improve quality of life. Liver cirrhosis of hepatitis B is divided into compensated and decompensated stages. There are some differences in the timing of receiving antiviral therapy for these two conditions of cirrhosis. In terms of antiviral treatment options, patients with compensated cirrhosis can choose interferon therapy or nucleoside therapy, both of which can slow down the progression of cirrhosis and reduce the occurrence of liver cancer. Therefore, it is advisable to choose nucleoside analogs with low resistance rate and strong efficacy. If drug resistance occurs, the antiviral regimen should be adjusted under the guidance of an experienced specialist; choosing interferon therapy should start with a small dose to avoid adverse reactions. For decompensated cirrhosis, nucleoside analogues are generally chosen for treatment, and the same attention should be paid to nucleoside analogues with low resistance rate and strong efficacy. The patient should also be treated with anti-inflammatory, anti-fibrotic and immune regulating therapy according to his condition. In addition to antiviral treatment, patients should also do a good job of self-care, especially when the symptoms are obvious or the disease is more serious bed rest, appropriate consumption of high-protein, high-calorie, high-fiber easily digestible food to facilitate liver repair